Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma.
Collagen XVI belongs to the family of fibril-associated collagens with interrupted triple helices (FACIT).It is overexpressed during the progression of oral squamous cell carcinoma (OSCC).The present data show a strong collagen XVI-dependent induction of MMP9 and an increase in OSCC cell invasion.We found activated read more integrin-linked kinase